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Title: Moving Towards an Innovative DNA Technology for Detection of Pharmaceuticals in Reclaimed Water

PROJECT NUMBER:

01-HHE-21T

PROJECT MANAGER:

Daniel M. Woltering (x), Ph.D.
The Water Research Foundation

PRINCIPAL INVESTIGATOR:

Seth W. Kullman, Ph.D.
North Carolina State University
swkullma@ncsu.edu

STATUS:

Completed

LAST UPDATED:

3/21/2007

TOTAL FUNDING:

$200,000.00

REPORT DESCRIPTION:

The goal of this research was to investigate the use of DNA microarrays as a bioanalytical tool for analysis of pharmaceuticals in treated waters that are intended for reuse. The results suggest that prototypic pharmaceuticals target molecular events associated with pharmaceutical-induced gene induction and repression in exposed organisms. Gene expression profiles can be evaluated as a means to discern pharmaceutical exposure. When fully developed, such a bioanalytical approach may provide an efficient and robust method for screening pharmaceuticals in reuse and other water matrices. Published by WERF. 100 pages. Soft cover and online and PDF. (2007)

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